Stress and neuropeptides.

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Stress-Related Neuropeptides and Addictive Behaviors: Beyond the Usual Suspects

Addictive disorders are chronic, relapsing conditions that cause extensive disease burden. Genetic factors partly account for susceptibility to addiction, but environmental factors such as stressful experiences and prolonged exposure of the brain to addictive drugs promote its development. Progression to addiction involves neuroadaptations within neurocircuitry that mediates stress responses an...

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Stress, neuropeptides, and feeding behavior: a comparative perspective.

Stress inhibits feeding behavior in all vertebrates. Data from mammals suggest an important role for hypothalamic neuropeptides, in particular the melanocortins and corticotropin-releasing hormone (CRH)-like peptides, in mediating stress-induced inhibition of feeding. The effects of CRH on food intake are evolutionarily ancient, as this peptide inhibits feeding in fishes, birds, and mammals. Th...

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Special issue on neuropeptides in stress and addiction: Overview.

Stress and addiction are strongly related conditions that feedback onto each other at several levels. For example, exposure to stressors can cause relapse to abuse of diverse substances with addictive properties. Conversely, withdrawal from drugs of abuse, or even the state of craving in the absence of overt withdrawal, can serve as stressors that produce many of the same physiological effects ...

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Neuropeptides.

The role of neuropeptides in modulating behavior is slowly being elucidated. With the sequencing of the C. elegans genome, the extent of the neuropeptide genes in C. elegans can be determined. To date, 113 neuropeptide genes encoding over 250 distinct neuropeptides have been identified. Of these, 40 genes encode insulin-like peptides, 31 genes encode FMRFamide-related peptides, and 42 genes enc...

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ژورنال

عنوان ژورنال: Journal of Nippon Medical School

سال: 1998

ISSN: 0048-0444,1884-0108

DOI: 10.1272/jnms1923.65.2